What is lactose intolerance?
Lactose is a disaccharide naturally found in dairy products including milk, yoghurt, cream, chocolate, ice cream and cheese.1 Itcan also be used as a flavour enhancer in processed foods such as potato chips, crackers, margarine and bread.2
Lactose malabsorption. Approximately 70% of the world’s population aged ten years or older is affectedby lactose malabsorption, i.e. the failure to absorb lactose in the small intestine due to lactase deficiency or other intestinalpathology, with most causes being genetically determined (see: “There are four types of lactase deficiency”).2,3 People from Middle Eastern countries (70%), Asia (64%) and Africa (63 – 65%) have higher rates of lactose malabsorption,while lower rates are reported in Eastern Europe, Russia and former Soviet Republics (47%), Northern America (42%) and Northern,Western and Southern European countries (28%).3 Within Asia, the prevalence of lactose malabsorption is estimatedto range considerably; from 58% in Pakistan to 100% in South Korea.3 Both males and females are affected equallyworldwide.4
Lactose intolerance. When lactose malabsorption, i.e. the inability to digest lactose, causes gastrointestinalsymptoms it is referred to as lactose intolerance (see: “Gastrointestinal symptoms characterise lactoseintolerance”).2 Many people with lactose malabsorption will not develop lactose intolerance.2 Thelikelihood of developing symptoms depends on the amount of lactose ingested, whether lactose is eaten with other foods thataffect transit through the intestine to the colon, the amount of lactase expression in the small intestine, compositionof the microbiome and history of gastrointestinal disorders or surgery.2
The estimated prevalence of lactose intolerance in New Zealand.
The prevalence of lactose intolerance is more difficult to estimate than lactose malabsorption as studies mainly relyon self-reported symptoms during a lactose challenge, which are rarely blinded; self-reported lactose intolerance has asensitivity of 30 – 71% and specificity of 25 – 87%.2, 5 Of the limited New Zealand data available, an increasedprevalence of lactose malabsorption in Māori and Pacific peoples has been observed compared to New Zealand Europeans, basedon breath hydrogen testing (see: “Laboratory tests have a limited role in diagnosing lactose intolerancein New Zealand”).6, 7 A study conducted in Christchurch in 2010 found that the overall prevalence of primarylactose intolerance determined by genetic testing was 8% (among 1,064 participants); of the 30 Māori and Pacific participants,the prevalence was 30%.8
There are four types of lactase deficiency that can result in lactose intolerance
Primary lactase deficiency is the most common cause of lactose intolerance (sometimes referred to aslactase non-persistence or adult or late-onset lactose intolerance).2 Lactase concentrations reach their peakaround the time of birth in most people, and decline after the usual age of weaning.2, 9 The timing and rateof this decline is genetically determined.10 Onset of primary lactase deficiency is typically subtle and progressiveover several years, with most people diagnosed in late adolescence or adulthood.2, 9, 10 However, acute developmentis also possible.10
Secondary lactase deficiency (also referred to as acquired lactase deficiency) is transitory and canoccur after a gastrointestinal illness that alters the intestinal mucosa resulting in reduced lactase expression.2,11 Secondary lactase deficiency is common in children after rotaviral (and other infectious) diarrhoea. Giardiasis,cryptosporidiosis and other parasitic infections of the proximal small intestine often lead to lactose malabsorption.9 Secondarylactase deficiency may also occur with coeliac disease, inflammatory bowel disease, small intestinal bacteria overgrowth,cows’ milk protein allergy (CMPA)-induced enteropathy and immune-related illnesses such as HIV.9 In addition,some medicines can cause villous atrophy resulting in secondary lactase deficiency, e.g. aminoglycosides, tetracyclines,colchicine, chemotherapy treatments.12 Secondary lactase deficiency usually resolves after one to two monthsbut may be permanent if caused by a long-term condition.
Developmental lactase deficiency (neonatal) occurs in premature infants.9 This conditionis usually temporary and rapidly improves as the intestinal mucosa matures.9 Lactase and other disaccharidasesare deficient until after 34 weeks gestation.9
Congenital lactase deficiency (alactasia) is a life-long genetic condition involving the complete deficiencyof lactase expression from birth, despite the person having an otherwise normal intestinal mucosa.2 Alactasiais extremely rare; it has been diagnosed in fewer than 50 people worldwide.2, 9
Gastrointestinal symptoms characterise lactose intolerance
In general, the symptoms of lactose intolerance are often non-specific, mild and vary between individuals.2, 11 Symptomsusually occur between 30 minutes and a few hours after the ingestion of lactose.13 The severity of symptomsis influenced by the degree of lactase deficiency and the amount of lactose consumed; typically the more lactose consumed,the more frequent or severe the symptoms.13 In children, diarrhoea is often more pronounced, particularly thosewith secondary lactose deficiency.9
Symptoms result from two main causes (see: “Pathophysiology of lactase deficiency”):2
- Undigested lactose acting as an osmotic laxative (diarrhoea, abdominal pain)
- Intestinal bacteria using lactose as a growth substrate, resulting in production of hydrogen, carbondioxide and methane gases (flatulence, dyspepsia, abdominal distension or borborygmi [stomach gurgling])
Lactase is an enzyme produced by cells located in the microvilli of the small intestine which hydrolyses dietary lactose(a disaccharide sugar) into glucose and galactose (monosaccharide sugars) for transport across the cell membrane. In theabsence or deficiency of lactase, unabsorbed lactose causes an influx of fluid into the bowel lumen, due to osmotic pressure.Unabsorbed lactose then enters the colon and is used as a substrate by intestinal bacteria, producing gas and short-chainfatty acids via fermentation. The fatty acids cannot be absorbed by the colonic mucosa, therefore more fluid is drawn intothe bowel. A proportion of the lactose can be absorbed but the overall result of ingestion is a substantial rise of fluidand gas in the bowel, causing the symptoms of lactose intolerance.2
Diagnosis of lactose intolerance
Lactose intolerance is usually diagnosed by dietary challenge
- Step 1: Rule out other causes
- Step 2: Dietary challenge
- Step 3: Further investigation, if dietary challenge inconclusive
Lactose intolerance can be suspected in people who report gastrointestinal symptoms following the ingestion of milk ormilk products. An accurate diagnosis is important as it can significantly relieve a person’s anxiety and help them to avoidinappropriate investigation and treatment. For people who present in primary care with severe or persistent gastrointestinalsymptoms, other potential causes should also be excluded (see: “Differential diagnoses to consider”). In particular, anunderlying secondary cause of lactose intolerance should be ruled-out in children, e.g. rotavirus infection, giardiasisor coeliac disease. Self-diagnosis of lactose intolerance is not recommended as it could lead to unnecessary dietary restrictionsand expense, lack of essential nutrients and most importantly, failure to detect a more serious gastrointestinal problem;other physiological and psychological factors can contribute to gastrointestinal symptoms that mimic lactose intolerance.14
A lactose-free diet should be trialled for two to four weeks when lactose intolerance is suspected.14 Itis important that all sources of lactose are eliminated, so patients should be advised to read food labels carefully toidentify “hidden” sources of lactose, which are particularly common in processed foods, e.g. whey, cheese, milk by-products,milk solids, milk powder.14 Lactose can then be re-introduced to the diet. If symptoms improve during the twoto four week period and return when lactose is reintroduced, the diagnosis can be made.14
N.B. Some prescription and over-the-counter medicines e.g. oral contraceptive pills and nitrofurantoin (100 mg, modifiedrelease), contain a small amount of lactose, but not enough to cause gastrointestinal symptoms in someone with lactose intolerance.11
If dietary challenge is inconclusive or self-reported symptoms are unreliable, further investigations may be required.However, laboratory testing for lactose intolerance (see below) will often not provide a definitive diagnosis and the availabilityof tests throughout New Zealand is variable.
Laboratory tests have a limited role in diagnosing lactose intolerance in New Zealand
Although laboratory testing is often cited in literature to aid in the diagnosis of lactose intolerance, most of thesetests are not widely accessible in New Zealand or not publicly funded, and some lack sensitivity and/or specificity. Ifthere is significant uncertainty concerning a diagnosis, consider asking your local laboratory if any additional tests areavailable, such as:2, 9, 14
- Breath hydrogen test - measuresthe level of hydrogen in exhaled air after ingestion of lactose, following overnight fasting. Currently considered the mostreliable laboratory method for diagnosing lactose malabsorption (sensitivity is 80 – 90%) but false negatives can occurdue to breath hydrogen production associated with other conditions unrelated to lactose digestion, e.g. gut motility disorders.Breath hydrogen testing is usually not possible in young children due to the need for wearing a tight-fitting mask.
- Lactose tolerance test –measures blood glucose levels after ingestion of lactose. Less reliable than the breath hydrogen test (sensitivityis 75%). Requires significant adherence and is not suitable for children.
- Faecal pH test – non-specificmarker for lactose (or other carbohydrate) malabsorption. A pH of < 6.0 suggests lactose intolerance. Because of thehigh rate of false-negative results, this test is only recommended in infants aged under two years.
- Faecal reducing substances –another indirect test for lactose (or other carbohydrate) malabsorption. A positive test suggests an absence of thecorresponding enzyme. However, false negatives can occur if the person has not recently ingested lactose.
- Small bowel disaccharidases –requires duodenal biopsy in secondary care. This test may occasionally be considered in the context of secondarylactose intolerance where a gastroscopy is being performed to determine an underlying cause (e.g. coeliac disease, Crohn’sdisease, protracted diarrhoea).
- Genetic testing for hereditary lactasepersistence – tests for a cytosine (C)/thymine (T) single nucleotide polymorphism upstream of the lactase gene;T/T or C/T genotypes are lactose tolerant, while C/C genotype is lactose intolerant15, 16
Do not routinely request skin prick or serum allergen-specific IgE tests as lactose intolerance is not immunemediated. However, these tests may be considered to rule out CMPA if this is suspected.
N.B. There are various online allergy testing services marketed to the public. These are recommended against by the AustralasianSociety of Clinical Immunology and Allergy (ASCIA) due to the potential for harms from misdiagnosis. The full ASCIA positionstatement is available here: www.allergy.org.au/images/stories/pospapers/ASCIA_HP_Evidence-Based_Vs_Non_Evidence-Based_Allergy_Tests_Treatments_2021.pdf
Differential diagnoses to consider
If a dietary challenge proves inconclusive, alternative diagnoses should be considered, including:17
- Irritable bowel syndrome
- Coeliac disease
- Diverticular disease
- Inflammatory bowel disease
- Bacterial infection, e.g. Clostridium difficile
- Parasitic disease, e.g. giardiasis
- Cystic fibrosis
- Inadvertent or excessive laxative ingestion,e.g. in products that act as natural laxatives
- Mechanical bowel compromise
- Bowel neoplasm or polyp
Dietary management of lactose intolerance
Lactose does not need to be completely restricted
- Step 1: Confirm diagnosis of lactose intolerance
- Step 2: Determine how much lactose can be tolerated without symptoms
- Step 3: Encourage gradual reintroduction of milk and milk products – this usually improves symptoms and tolerance
The complete avoidance of all lactose-containing foods is not recommended to manage primary lactose intolerance.1 Instead,people should start with a more restricted diet and gradually increase the consumption of lactose-containing foods accordingto their individual tolerance level.18 Consistency is the key to building tolerance; continual exposure oftenenhances the number and efficiency of colonic bacteria capable of metabolising lactose, thereby producing fewer symptoms.19 Themajority of people, including children, can tolerate up to 5 g of lactose (approximately ½ cup milk) on its own, and upto one to two cups of milk in total per day, when eaten with other foods (e.g. cereal) or spread out across the day.1,2 Consuming lactose with meals rather than on an empty stomach slows the release of lactose in the small intestine,and people can experiment to see which foods are more tolerable.18
Some lactose-containing foods are better tolerated than others
Better tolerated dairy products include yoghurt with live culture and hard cheese (especially aged) because the lactoseis partially hydrolysed by bacteria during preparation and gastric emptying is slower due to their thicker consistency.1,9 Dairy products with a higher fat content or higher osmolality are also better tolerated due to delayed gastric emptying,e.g. ice cream or chocolate milk.20 Symptoms may be more severe with skim milk (green top) than whole milk dueto the higher lactose and lower fat content.1, 20
Probiotics may be beneficial for some people
Probiotic supplementation may be beneficial for symptom relief in some people with lactose intolerance by promoting lactosedigestion.21 A 2020 systematic review of randomised controlled trials found an overall positive association betweenprobiotic supplementation and reduced gastrointestinal symptoms of lactose intolerance, although the effect size variedand the quality of evidence was low.21 Probiotic strains that were shown to be beneficial included Lactobacillusacidophilus, L. reuteri, L. rhamnosus and L. bulgaricus, Streptococcus thermophilus and Bifidobacteriumlongum (dose range 108 – 1011 colony-forming units [CFU] per day).21
Lactose-free milks and milk alternatives are usually not required
Lactose-free milk or milk alternatives are generally not necessary unless large quantities of milk are consumed, or inthe rare case of intolerance to even small amounts of milk (in which case lactose-free foods may also need to be considered).If these alternatives are required, the milk substitutes selected should be fortified with calcium and vitamin D to preventdeficiencies.22 For children aged under five years, almond, coconut, rice and oat milk alternatives should notbe used as the main milk source as they are not nutritionally adequate.22 Fortified soy milk is recommended ifan alternative to cows’ milk is required in children. N.B. Soy milk or infant formula is generally not advised in childrenaged under 12 months (see: “Feeding options for infants”).23
Maintaining calcium and vitamin D intake when minimising lactose in the diet
Adequate calcium and vitamin D intake are particularly important during childhood and adolescence for optimal peak bonemass.24 People with lactose intolerance should continue to have at least two servings of milk or milk productsdaily if tolerated in multiple small doses or with food.22 If this is not possible, calcium-fortified milk orfortified milk substitutes should be considered as tolerated, and the diet should be supplemented through intake of non-dairycalcium-rich food, e.g. bony fish, tofu, dark green leafy vegetables and nuts and seeds.1, 22 As sunlight isthe primary source of vitamin D, all people should be advised to take a daily walk or other form of outdoor activity.25
Lactase enzymes may be helpful alongside dietary management
Lactase enzyme supplements (available over-the-counter, not funded) should be considered as an adjunct, not a substitutefor dietary management; if dairy products can be tolerated in small amounts, enzyme supplements are unnecessary.2 Enzymesupplements may not completely relieve symptoms and it is difficult to determine the effective dose.2
Feeding options for infants with lactose intolerance
In general, infants with lactose intolerance should continue breastfeeding.9 Breastfeeding mothers do not haveto eliminate lactose containing foods from their diets; the amount of lactose present in breastmilk is largely independentof maternal consumption.9 Formula-fed infants may initially require a lactose-free formula, but reintroductionof lactose containing formula or foods should be trialled after two to four weeks, as tolerated.9 In New Zealand,lactose-free and soy milk infant formulas are available from supermarkets and pharmacies (not funded). Ongoing use of soyformula in infants aged under 12 months is generally not recommended, but could be considered in infants aged over six monthsif they are unable to tolerate adequate quantities of cows’ milk formula.23 Lactose-free infant formula can beused in infants from birth.26
N.B. For guidance on feeding for infants with CMPA, see: bpac.org.nz/2019/cmpa.aspx
Managing secondary lactose intolerance
Short periods of lactose intolerance are common in children following infectious diarrhoea.27 In infants agedunder three months or malnourished children, this may negatively influence recovery from the primary illness.28 Ameta-analysis of clinical trials found that a lactose-free diet in non-breastfed infants may reduce the duration of diarrhoeaby up to 18 hours.27 Diluting lactose-containing milk has not been shown to resolve diarrhoea earlier comparedto undiluted milk (low quality evidence).27 Breastfed infants with temporary lactose intolerance can continueto safely breastfeed.9
In general, treatment of the cause of the secondary lactase deficiency will lead to restoration of lactase activity.9 Therefore,a lactose-free diet is usually only required temporarily until secondary lactase deficiency resolves.
In cows’ milk allergy, children are allergic to the protein in milk.
CMPA is one of the most common food allergies in young children (prevalence of 2 – 3% of children before age three years).29 Theprevalence in adults is much lower (approximately 0.5%).30 CMPA is reported to resolve in approximately halfof children before age 12 months, and in up to 90% by age five years.31
There are two types of clinical manifestation of CMPA:29
- IgE-mediated (Immediate): Symptoms usually develop within minutes to one hour after ingestion of cows’milk. Symptoms include eczema, urticaria, rhinitis, cough, wheezing, abdominal pain, vomiting, diarrhoea. Life threateninganaphylaxis is possible but rare.
- Non-IgE mediated (Delayed): Symptoms typically occur more than two hours or even days following ingestionof cows’ milk. Symptoms include vomiting, diarrhoea, blood in stools, with or without eczema.
Differentiating between lactose intolerance and CMPA:
- CMPA can manifest during breastfeeding (due to cows’ milk ingested by the mother), in an infant on a cows’ milk-basedformula or shortly after weaning. Lactose intolerance is usually seen after age two years.
- Infants with lactose intolerance may safely breastfeed without the need for any maternal dietary modification, but mothersmay need to remove dairy products from their diet if their infant is diagnosed with CMPA
- Children with lactose intolerance can usually tolerate small amounts of dairy products, whereas in milk allergy, smalltraces usually cause symptoms. N.B. IgE mediated CMPA reactions typically have a more rapid onset than non-IgE-mediatedreactions or symptoms of lactose intolerance.29
- Differentiation is usually possible based on clinical symptoms
For further detail on the diagnosis and management of CMPA, see “Managing cows’ milk protein allergy in infants”,available from: bpac.org.nz/2019/cmpa.aspx
Clinician’s Notepad: lactose intolerance
If a person reports gastrointestinal symptoms that consistently occur following the ingestion of milk or milk products
- First rule out other possible causes of symptoms – particularly if symptoms are severe or persistent, e.g. irritable bowel syndrome, inflammatory bowel disease
- Secondary causes should be strongly considered in children, e.g. rotavirus infection, giardiasis or coeliac disease
- If there is no other obvious cause, a lactose-free diet should be trialled for two to four weeks; ensure the patient is aware of “hidden” sources of lactose which are common in processed foods
- At the end of the trial, the patient should re-introduce lactose; if symptoms have improved during the trial and return when lactose is reintroduced, then this is sufficient to diagnose lactose intolerance
- Do not routinely request skin prick or serum allergen-specific IgE tests unless cows’ milk protein allergy is suspected as lactose intolerance is not immune-mediated
- If the dietary challenge is inconclusive or there is uncertainty, discuss with your local laboratory whether additional testing is available, e.g. breath hydrogen testing, or consult with a secondary care clinician
Management of lactose intolerance
- Lactose usually does not need to be excluded from the diet; people should start with a more restricted diet and gradually increase the consumption of lactose-containing foods according to individual tolerance level
- Most people can tolerate up to 5 g of lactose (approximately ½ cup milk) on its own, and up to one to two cups of milk in total per day, when eaten with other foods or spread out across the day
- Some lactose-containing foods are better tolerated than others, e.g. yoghurt with live culture or dairy products with higher fat content
- Lactose-free milks and alternative milks are usually not required but if used (or if sufficient quantities of cow’s milk cannot be consumed) must be fortified with calcium and vitamin D to meet the recommended intake
- Probiotics or lactase enzyme supplements (not funded) may be beneficial for some people alongside dietary management, however, these are not routinely required and efficacy varies
- Infants with lactose intolerance should continue breastfeeding and the mother does not need to eliminate lactose from her diet; lactose-free infant formulas are available, if required
- A temporary lactose-free diet may be beneficial for people with secondary lactose intolerance, e.g. following a bout of infectious diarrhoea, to promote recovery from the primary illness