Women's Healthcare Solutions | Pre-Seed Clinical Validations (2024)

Table of Contents
Clinically Shown to Be Fertility-Friendly The Effects of vagin*l Lubricants on Sperm Function In Vitro Effects of Coital Lubricants and Synthetic and Natural Oils on Sperm Motility Effect of an Isotonic Lubricant on Sperm Collection and Sperm Quality What should it take to describe a substance or product as 'sperm safe' Sperm Toxicity of ‘Nonspermicidal’ Lubricant and Ultrasound Gels Used in Reproductive Medicine. Quantitative Perceptual Differences Among Over-the-Counter vagin*l Products Effect of vagin*l Lubricants on Sperm Motility and Chromatin Integrity: Prevalence of vagin*l Dryness in Trying-to-Conceive Couples. Products for Sexual Lubrication: Understanding and Addressing Options With Your Patients. Optimizing Natural Fertility. Dyspareunia and vagin*l Dryness after Breast Cancer Treatment Cancer and Sexual Health Male Infertility: Problems and Solutions A Practical Guide to Basic Laboratory Andrology Love Sex Again: A Gynecologist Finally Fixes the Medical Problems That Are Sabotaging Your Sex Life Hardcover Fertility for Beginners: The Fertility Diet and Health Plan to Start Maximizing Your Fertility Paperback Fertility Preservation in Male Cancer Patients Hot and Fast: Sexy, Spontaneous Quickies for Passionate org*sms Paperback An Introduction to Male Reproductive Medicine Hacker & Moore’s Essentials of Obstetrics and Gynecology Maternity and Pediatric Nursing Men's Sexual Health and Fertility: A Clinician's Guide [Hardcover] Surgical and Medical Management of Male Infertility[Hardcover] Managing The Stress Of Infertility: How To Balance Your Emotions, Get The Support You Need, And Deal With Painful Social Situations When You're Trying To Become Pregnant Paperback FAQs
  1. Home
  2. Clinical Studies
  3. Pre-Seed™ Clinical Validations

Clinically Shown to Be Fertility-Friendly

Read about Pre-Seed™ Fertility-Friendly Lubricant's efficacy and how the first lubricant to be sperm friendly as confirmed by independent studies has helped patients conceive.

Women's Healthcare Solutions | Pre-Seed Clinical Validations (1)

  • PUBLICATIONS
  • CLINICAL TEXTBOOK MENTIONS

Publications

The Effects of vagin*l Lubricants on Sperm Function

The Journal of Assisted Reproduction and Genetics. January 2014
Alex Mowat, Cora Newton, Clare Boothroyd, Kristy Demmers & Steven Fleming

VIEW ABSTRACTS

In Vitro Effects of Coital Lubricants and Synthetic and Natural Oils on Sperm Motility

Fertility and Sterility. February 2014
Ranjit S. Sandhu, B.S., Timothy H. Wong, B.A., Crystal A. Kling, B.S., and Kazim R. Chohan, Ph.D.

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Effect of an Isotonic Lubricant on Sperm Collection and Sperm Quality

Fertility and Sterility. 2013; 99, 4
Ashok Agarwal, Ph.D., Helena Malvezzi, M.S., , Rakesh Sharma, Ph.D.

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What should it take to describe a substance or product as 'sperm safe'

Human Reproduction Update, Vol. 19, Supplement l pp. il-i48, 2013

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Sperm Toxicity of ‘Nonspermicidal’ Lubricant and Ultrasound Gels Used in Reproductive Medicine.

Fertility & Sterility. 2011;95:835-836

VIEW ABSTRACTS

Quantitative Perceptual Differences Among Over-the-Counter vagin*l Products

Using a Standardized Methodology. Contraception. 2011;84:184-193

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Effect of vagin*l Lubricants on Sperm Motility and Chromatin Integrity:

A Prospective Comparative Study.
Fertility & Sterility. 2008 Feb;89:375-379

VIEW ABSTRACTS

Prevalence of vagin*l Dryness in Trying-to-Conceive Couples.

Pacific Coast Reproductive Society, April 2003

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Medical Reviews & Guidelines

Products for Sexual Lubrication: Understanding and Addressing Options With Your Patients.

Nursing for Women's Health. 2011 Jun/Jul;15:253-257

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Optimizing Natural Fertility.

Fertility & Sterility. 2008 Nov;90(Suppl 3):S1-S6

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Dyspareunia and vagin*l Dryness after Breast Cancer Treatment

Dyspareunia and vagin*l Dryness after Breast Cancer Treatment

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Clinical Textbook Mentions

Women's Healthcare Solutions | Pre-Seed Clinical Validations (2)

Cancer and Sexual Health

JP Mulhall © 2011

In this reference book for cancer care providers, Pre-Seed is listed as a water-soluble lubricant that does not decrease sperm motility.

Women's Healthcare Solutions | Pre-Seed Clinical Validations (3)

Male Infertility: Problems and Solutions

ES Sabanegh MD © 2011

The chapter on the initial consultation for male infertility states: "In 2008, in vitro studies suggest that a newer commercially available hydroxyethylcellulose-based lubricant, such as Pre-Seed, has minimal deleterious effects on mobility and sperm chromatin integrity.”

Women's Healthcare Solutions | Pre-Seed Clinical Validations (4)

A Practical Guide to Basic Laboratory Andrology

L Bjorndahl, D Mortimer, et al. © 2010

In this laboratory guide, the authors state: "If a lubricant must be used then it must not show any toxicity to spermatozoa. Currently, the only suitable commercial product for this particular purpose is Pre’, an external use version of the Pre-Seed vagin*l lubricant…"

Women's Healthcare Solutions | Pre-Seed Clinical Validations (5)

Love Sex Again: A Gynecologist Finally Fixes the Medical Problems That Are Sabotaging Your Sex Life Hardcover

by Lauren Streicher (Author)

Dr. Streicher, a leading women's sexual health expert, recommends Pre-Seed Fertility Friendly Lubricant for women who are trying to conceive. Women who are having timed intercourse to coincide with ovulation may find that some extra lubrication can make sex more enjoyable. Pre-Seed is recommended by Dr. Streicher because it does not affect sperm viability and is less irritating than most leading lubricants.

Women's Healthcare Solutions | Pre-Seed Clinical Validations (6)

Fertility for Beginners: The Fertility Diet and Health Plan to Start Maximizing Your Fertility Paperback

by Shasta Press (Author)

Fertility for Beginners is a guide to healthy and effective methods for increasing your fertility naturally, and getting one step closer to becoming pregnant. One of the questions this book answers is whether lubricants can be used during sex when you are trying to get pregnant. Pre-Seed Fertility-Friendly lubricant is mentioned because it mimics the body’s natural lubrication and provides an optimal, pH balanced environment for sperm. However, most other lubricants, from vegetable oil to petroleum jelly to saliva, can kill sperm.

Women's Healthcare Solutions | Pre-Seed Clinical Validations (7)

Fertility Preservation in Male Cancer Patients

by Doctor John P. Mulhall, Linda D. Applegarth, Doctor Robert D. Oates and Doctor Peter N. Schlegel (Apr 8, 2013)

Written by international authorities in the field of fertility preservation, this comprehensive book reviews the impact of cancers and cancer treatment on male fertility, the available fertility preservation strategies and post-treatment management. Pre-Seed Fertility Friendly lubricant is recommended as a coital lubricant because studies show it had no apparent detrimental effects on sem*n motility or chromatin integrity.

Women's Healthcare Solutions | Pre-Seed Clinical Validations (8)

Hot and Fast: Sexy, Spontaneous Quickies for Passionate org*sms Paperback

by Megan Andelloux (Author)

This book features everything you need to know for fast, fun, sexy encounters. It also includes a section on sex for those who are trying to get pregnant. While recognizing that scheduled intercourse can be tedious, the author offers a helpful solution to make sex more fun and still be safe for use when trying to conceive – Pre-Seed Fertility Friendly lubricant.

Women's Healthcare Solutions | Pre-Seed Clinical Validations (9)

An Introduction to Male Reproductive Medicine

C Niederberger MD © 2011

In this medical text written by well-renowned experts, Dr. Craig Niederberger writes: "Virtually all lubricants impair sperm, including saliva. However, some couples need lubricants for intercourse. A recent survey of the effects of various lubricants on sperm motility and DNA quality suggested that Pre-Seed appears to have the least negative effect on sperm.”

Women's Healthcare Solutions | Pre-Seed Clinical Validations (10)

Hacker & Moore’s Essentials of Obstetrics and Gynecology

N Hacker MD, J Gambone DO, MPH, C Hobel MD © 2010

In this classic textbook for medical students, the authors write: "Lubricants may be toxic to sperm. A nontoxic lubricant, Preseed, has been developed for infertile couples."

Women's Healthcare Solutions | Pre-Seed Clinical Validations (11)

Maternity and Pediatric Nursing

S Scott Ricci & T Kyle © 2009

In this book for nursing professionals, Pre-Seed is listed as a water-soluble lubricant that can reduce discomfort during intercourse.

Women's Healthcare Solutions | Pre-Seed Clinical Validations (12)

Men's Sexual Health and Fertility: A Clinician's Guide [Hardcover]

by John P. Mulhall, Wayland Hsiao

Men’s Sexual Health and Fertility focuses on the interplay and interconnections between male sexual dysfunction and male factor infertility. In this book, the authors cite research that has shown that many lubricants have demonstrated varied effects on sperm including reduced viability, altered morphology, DNA damage and impaired motility. However, the authors also mention that Pre-Seed Fertility Friendly lubricant was studied and was shown to have minimal impact on sem*n parameters as compared to other lubricants like Astroglide and Pre-Seed.

Women's Healthcare Solutions | Pre-Seed Clinical Validations (13)

Surgical and Medical Management of Male Infertility[Hardcover]

by Marc Goldstein MD, Doctor Peter N. Schlegel MD

With contributions from world-renowned experts, this comprehensive overview of male infertility covers anatomy, evaluation, treatment and prevention. Research shows that most coital lubricants can significantly impair sperm motility and adversely affect fertility. However, in a comparative study, Pre-Seed Fertility-Friendly lubricant was shown to not cause a significant decrease in sperm motility or chromatin integrity.

Women's Healthcare Solutions | Pre-Seed Clinical Validations (14)

Managing The Stress Of Infertility: How To Balance Your Emotions, Get The Support You Need, And Deal With Painful Social Situations When You're Trying To Become Pregnant Paperback

by Carol Fulwiler Jones MA (Author)

In this step-by-step infertility guide, Pre-Seed Fertility Friendly lubricant is recommended to help with painful intercourse. Pre-Seed is recommended as safe to use during infertility.

Women's Healthcare Solutions | Pre-Seed Clinical Validations (2024)

FAQs

Does Pre-Seed really work trying to conceive? ›

Does Pre-Seed lubricant help you get pregnant? No. Fertility-friendly lube is made from ingredients that will not damage sperm, but it does not enhance the chances of pregnancy.

What is the success rate of Pre-Seed? ›

The average pre-seed stage startup usually gets between $50,000 and $200,000 within a fundraise of 3 to 9 months. About 60% of companies that raise pre-seed funding fail to make it to the next startup stage, Series A.

Does Pre-Seed keep sperm alive? ›

(In one study, PreSeed appeared to decrease sperm motility by about 4% after 30 minutes, but prolonged exposure did not result in further damage.)

Do I have to wait 15 minutes for Pre-Seed? ›

Instructions for How to Use Pre-Seed Fertility Friendly lubricant. Many women choose to apply the lubricant about 15 minutes prior to intercourse to allow moisture to disperse. You may apply Pre-Seed™ up to an hour before sex.

Do doctors recommend Pre-Seed? ›

SKIP THE LUBE…

If you can't live without lube, Masterson says you can use Pre-Seed, an FDA-approved “fertility-friendly” lubricant developed by doctors. It's pH-balanced to match fertile cervical mucus as well as the pH of his sperm, so it won't hurt your odds of conceiving.

Which seed is best for conceiving? ›

Pumpkin seeds, hemp seeds, pinenuts, cashews, almonds and sunflower seeds are just some of the nuts and seeds that are great for providing zinc, which is needed for healthy egg and sperm. Walnuts, pecans, sunflower seeds, almonds, pumpkin seeds and brazil nuts are particularly rich in antioxidant properties.

What are the disadvantages of Pre-Seed? ›

Disadvantages of pre-seed funding

Pre-seed funding rounds are typically smaller than later rounds of funding, which means that startups may not be able to raise all the money they need to get to the next level.

Is it better to use Pre-Seed or nothing? ›

Helping Overcome vagin*l Dryness When Trying to Get Pregnant

Adequate lubrication of the right kind can help – not hinder – sperm along their journey. Clinical studies show that non-sperm friendly lubricants may limit sperm motility while Pre-Seed™ Fertility Lubricant does not interfere with sperm function.

Is Pre-Seed funding worth it? ›

Importance of Pre-seed Funding

It's a key step that shapes your venture's future. This helps you dive into market research, build a prototype, or put together a killer team. These aren't small tasks—they're the backbone of your startup's story.

Which is better, Pre-Seed or conceive plus? ›

Pre-seed® was the lubricant which had the least negative effect on sperm function, with Conceive Plus® a close second, due to the significantly higher sperm motility and vitality parameters measured following lubricant exposure.

Is Pre-Seed FDA approved? ›

Created by pregnancy test brand First Response, Pre-Seed is an FDA-cleared fertility-friendly lubricant.

What lube is good for getting pregnant? ›

So, what should you do if you use lubricants during sex and are trying to get pregnant? Search for a lubricant that is hydroxyethylcellulose-based. These lubricants don't decrease sperm motility and are the most similar in consistency and viscosity to natural vagin*l mucus.

How long to let sperm sit to get pregnant? ›

After Intercourse

But several commonsense steps may help the sperm on their journey to reach and fertilize an egg. Lie still. Doing this for a spell can help sperm get where they're going. About 10-15 minutes should do it.

How to make sure sperm stays inside you? ›

This means that the smallest amount of sem*n escapes and is retained as close to the cervix (the neck of the uterus) as possible. The woman can try lying on her back with her lower back elevated on a small pillow for around 20-30 minutes. This will help to tilt the vagin* backwards so the sem*n pools around her cervix.

How long to keep legs up to get pregnant? ›

You have probably heard this one: Lie in bed with your feet in the air after having sex to increase your chances of getting pregnant. The verdict? Not (totally) true. "It's good advice to lay in bed for 10 to 15 minutes after intercourse, but you don't need your feet in the air," Goldfarb says.

Is seed cycling safe while trying to conceive? ›

Plenty of anecdotal evidence abounds about seed cycling helping fertility issues, but the scientific evidence is lacking. However, there are a number of health benefits that can be realized by adding seeds to your diet that may or may not impact fertility issues.

How often should you have seed to get pregnant? ›

Generally, the best chance of pregnancy is when sex happens 1-2 days before ovulation. If you have a regular 28-day cycle, count back 14 days from when you expect your next period to start. Plan on having sex every other day around that time -- say, days 12 and 14.

Does Pre-Seed work reviews? ›

Well it worked! After 5 months of trying to conceive, using saliva as lube, with no success, I learned that saliva is bad for sperm motility. I looked into conception safe lubes and found this one. It feels great, texture wise.

How does Pre-Seed help sperm? ›

The Pre-Seed patented formula was uniquely developed by a woman Sperm Physiologist to match fertile cervical mucus in pH, osmolality and viscosity, thus providing an optimal environment for sperm in women who are trying to conceive. Most lubricants harm sperm and should not be used while trying to conceive.

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