Type 2 diabetes - Understanding medicine (2024)

Most people need medicine to control their type 2 diabetes.

This helps keep your blood sugar level as normal as possible to prevent health problems.

You may have to take it for the rest of your life, although your medicine or dose may need to change over time.

Adjusting your diet and being active is usually also necessary to keep your blood sugar level down.

Medicines for type 2 diabetes

There are many types of medicine for type 2 diabetes. It can take time to find a medicine and dose that's right for you.

You'll usually be offered a medicine called metformin first.

You may need to take extra medicines, or a different medicine such as insulin, if:

  • metformin is not suitable for you
  • treatment is not keeping your blood sugar levels below your target
  • you have other health problems, such as heart problems or kidney problems

Your GP or diabetes nurse will recommend the medicines most suitable for you.

Your medicine might not make you feel any different, but this does not mean it's not working. It's important to keep taking it to help prevent future health problems.

Metformin

Metformin is the most common medicine used for type 2 diabetes. It can help keep your blood sugar at a healthy level.

It comes as tablets.

Common side effects of metformin include feeling sick and diarrhoea. If this happens to you, your doctor may suggest trying a different type called slow-release metformin.

Find out more about metformin

Other diabetes medicines

If metformin does not work well enough on its own, you cannot take it or you have other health problems, you may need to take other medicines alongside or instead of metformin.

These include:

  • other tablets that help lower your blood sugar, such as gliclazide, glimepiride, alogliptin, sitagliptin or pioglitazone
  • tablets that lower your blood sugar and help your heart pump blood around your body, such as dapagliflozin, empagliflozin, ertugliflozin or canagliflozin
  • injections or tablets that lower your blood sugar and help you lose weight, such as semaglutide, dulaglutide or tirzepatide

Insulin

You'll need insulin if other medicines no longer work well enough to keep your blood sugar below your target.

Sometimes you may need insulin for a short time, such as if you're pregnant, if you're ill, or to bring your blood sugar level down when you're first diagnosed.

You inject insulin using an insulin pen. This is a device that helps you inject safely and take the right dose.

Using an insulin pen does not usually hurt. The needles are very small, as you only inject a small amount just under your skin. Your diabetes nurse will show you where to inject and how to use your pen.

Your GP or diabetes specialist will recommend the type of insulin treatment that's best for you.

Find out more about insulin

Side effects

Your diabetes medicine may cause side effects.

The side effects you may get depend on which medicines you're taking.

Do not stop taking your medicine if you get side effects. Talk to your doctor, who may suggest trying a different medicine.

Low blood sugar (hypos)

Some diabetes medicines can cause low blood sugar, known as hypoglycaemia or a hypo. These medicines include insulin and medicines such as gliclazide.

If you take medicine that can cause hypos, your doctor might recommend that you check your blood sugar regularly. You'll be given a testing kit and shown how to do a finger-prick test.

If you take insulin at least twice a day and have frequent or severe hypos, you might also be offered a continuous glucose monitor (CGM) or flash monitor.

This is a small sensor you wear on your skin that lets you check your blood sugar level at any time.

Learn more about checking your blood sugar levels from Diabetes UK

You'll need to check the DVLA rules about driving if you take medicine that can cause hypos.

Learn more about diabetes and your driving licence from Diabetes UK

How to get free prescriptions for diabetes medicine

If you take diabetes medicine, you're entitled to free prescriptions for all your medicines, including medicines for other conditions.

To claim your free prescriptions, you'll need to apply for an exemption certificate.

To apply for an exemption certificate:

  • fill in an FP92A form at your GP surgery
  • you should get the certificate in the post about a week later – it'll last for 5 years
  • take it to your pharmacy with your prescriptions

If you have to pay for diabetes medicine before you receive your exemption certificate, save your receipts and ask the pharmacist to give you an FP57 receipt and refund claim form. You can use this to claim the money back after you receive your certificate.

Travelling with diabetes medicines

If you're going on holiday:

  • pack extra medicine – speak to your diabetes nurse about how much to take
  • carry your medicine in your hand luggage just in case checked-in bags go missing or get damaged
  • get a letter from your GP that says you need medicine and to carry medical supplies to treat diabetes if you're going abroad (you may need to pay for the letter)

Page last reviewed: 22 December 2023
Next review due: 22 December 2026

Type 2 diabetes - Understanding medicine (2024)

FAQs

What is the basic explanation of type 2 diabetes? ›

Type 2 diabetes, the most common type of diabetes, is a disease that occurs when your blood glucose, also called blood sugar, is too high. Blood glucose is your main source of energy and comes mainly from the food you eat. Insulin, a hormone made by the pancreas, helps glucose get into your cells to be used for energy.

How does type 2 diabetes medication work? ›

A medication may work by: Causing the pancreas to make and release more insulin. Limiting the liver's ability to make and release sugar. Blocking the action of enzymes in the intestines that break down carbohydrates, slowing how quickly cells take in carbohydrates.

What is the most prescribed medication for type 2 diabetes? ›

One commonly prescribed medication for type 2 diabetes is metformin, which belongs to a class of medications known as biguanides. This medication is taken daily by mouth. The medication makes your liver and muscles more sensitive to insulin and reduces glucose production in the liver.

What is the new drug replacing metformin? ›

Mounjaro is a weekly injection approved for adults. Metformin is an oral medication approved for people as young as 10 years old. Mounjaro provides better blood glucose (sugar) control and more potential weight loss than metformin. But metformin is often more cost-effective for many people.

How do you explain diabetes in simple terms? ›

Diabetes is a chronic, metabolic disease characterized by elevated levels of blood glucose (or blood sugar), which leads over time to serious damage to the heart, blood vessels, eyes, kidneys and nerves.

How do you feel when your blood sugar is too high? ›

increased thirst and a dry mouth. needing to pee frequently. tiredness. blurred vision.

What organ is metformin hard on? ›

The continuation of metformin therapy was significantly associated with a decline in renal function in the patients with DM and moderate CKD. Other risk factors for a decline in renal function included high serum LDL-C, high HbA1c, low baseline eGFR, high uric acid level, high UACR, and the use of ACEIs and/or ARBs.

Why do doctors no longer recommend metformin? ›

However, the toll it takes on the digestive system may prevent many people with diabetes from taking it for more than a week or two. “Metformin commonly causes gastrointestinal symptoms such as diarrhea and flatulence,” explained a recent study published in the journal Diabetes, Obesity and Metabolism.

Do you lose weight on metformin? ›

Many people with diabetes who are prescribed metformin lose around 2% to 3% of their body weight within the first year of starting the drug.

What foods should I avoid with diabetes? ›

You avoid eating simple carbs (such as sweets), saturated fats, and most meat-based protein. The diet can be hard for some people to follow for a long time because it's very low-fat (less than 10% of your daily calories), but you can find some meal plans with a bit more flexibility.

At what A1C should you start metformin? ›

Rather, individuals at the highest risk for developing diabetes-i.e., those with FPG concentrations of 110-125 mg/dL (6.1-6.9 mmol/L) or A1C levels of 6.0-6.4% (42-46 mmol/mol) or women with a history of gestational diabetes mellitus-should be followed closely and metformin immediately introduced only when they are ...

Why is metformin being taken off the market? ›

The company is recalling metformin because it contains N-nitrosodimethylamine (NDMA) above the acceptable intake limit. FDA publishes a recalled metformin list including details about metformin products that have been recalled.

What is the best medicine to lower A1C? ›

FARXIGA can help with your first priority—lowering your A1C

FARXIGA is a once-daily pill proven to help lower A1C, along with diet and exercise. *Average reduction with 5mg + metformin XR when starting at 9.2% A1C. Metformin XR alone lowered A1C by 1.4% when starting at 9.1% A1C. Individual results may vary.

What food works like metformin? ›

But if you're looking for other ways to control your blood sugar, consider these natural alternatives to metformin.
  • Berberine. Berberine is an organic compound found in many plants in the Berberis genus, including barberry, Oregon grape, and tree turmeric. ...
  • Inositol. ...
  • Curcumin. ...
  • Cinnamon.
Feb 23, 2024

What is an explanation of Type II diabetes what goes wrong ?)? ›

In type 2 diabetes, the pancreas makes insulin, but the cells don't respond to it as they should. This is called insulin resistance. When glucose can't get into cells, the blood sugar level rises. Then the pancreas works harder to make even more insulin.

What is the nice definition of type 2 diabetes? ›

Type 2 diabetes is a chronic metabolic condition characterised by insulin resistance (that is, the body's inability to effectively use insulin) and insufficient pancreatic insulin production, resulting in high blood glucose levels (hyperglycaemia).

What is difference diabetes type 1 & 2? ›

Diabetes type 1 and type 2 come from different causes: In diabetes type 1, the pancreas does not make insulin, because the body's immune system attacks the islet cells in the pancreas that make insulin. In diabetes type 2, the pancreas makes less insulin than used to, and your body becomes resistant to insulin.

What is diabetes type 2 concept? ›

Type 2 diabetes happens when your body can't use insulin properly. Without treatment, Type 2 diabetes can cause various health problems, like heart disease, kidney disease and stroke. You can manage this disease by making lifestyle changes, taking medications and seeing your healthcare provider for regular check-ins.

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