@BrandishedSword1 Hayhor's suggestion is a great combo, with the more advanced version being Catalyst and Seer.
Wraith is strong with any legend as she is essentially the support carry, thanks to her tactical and ultimate abilities. When playing as Wraith, I tend to prefer having Pathfinders on my team for their mobility.
Caustic and Wattson make a toxic and powerful duo, especially when playing in buildings.
Revenant and Octane are also a strong pair, with Revenant's ultimate ability and Octane's jump pad allowing them to quickly get the drop on enemies. Ash and Revenant are also a fun combination.
Horizon and Fuse make for a nice combo as well, with Fuse able to cluster Horizon's ultimate and land grenades on enemies
