Nail fungus - Diagnosis and treatment (2024)

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Diagnosis

Your health care provider will examine your nails and perhaps take some nail clippings or scrape debris from under your nail. These samples are sent to a lab to identify the cause of your symptoms.

Other conditions, such as psoriasis, can mimic a fungal infection of the nail. Microorganisms such as yeast and bacteria also can infect nails. Knowing the cause of your infection helps determine the best treatment.

Treatment

Treatment for toenail fungus isn't always needed. And sometimes self-care and nonprescription products clear up the infection. Talk with your health care provider if your condition doesn't improve. Treatment depends on the severity of your condition and the type of fungus causing it. It can take months to see results. And even if your nail condition improves, repeat infections are common.

Medications

Your health care provider may prescribe antifungal drugs that you take by mouth (orally) or apply to the nail.

  • Oral antifungal drugs. These drugs are often the first choice. One option is itraconazole (Sporanox). These drugs help a new nail grow free of infection, slowly replacing the infected part.

    You typically take this type of drug daily for 6 to 12 weeks. But you won't see the end result of treatment until the nail grows back completely. It may take four months or longer to eliminate an infection. Treatment success rates with these drugs appear to be lower in adults over age 65.

    Oral antifungal drugs may cause side effects such as rash and liver damage. Or they may interfere with other prescription drugs. You may need occasional blood tests to check on how you're doing with these types of drugs. Health care providers may not recommend oral antifungal drugs for people with liver disease or congestive heart failure or those taking certain medications.

  • Medicated nail polish. Your health care provider may prescribe an antifungal nail polish called ciclopirox (Penlac). You paint it on your infected nails and surrounding skin once a day. After seven days, you wipe the piled-on layers clean with alcohol and begin fresh applications. You may need to use this type of nail polish daily for almost a year.
  • Medicated nail cream. Your health care provider may prescribe an antifungal cream, such as efinaconazole (Jublia) and tavaborole (Kerydin). You rub this product into your infected nails after soaking. These creams may work better if you first thin the nails. This helps the medication get through the hard nail surface to the underlying fungus.

    To thin nails, you apply a nonprescription lotion containing urea. Or your health care provider may thin the surface of the nail (debride) with a file or other tool.

    Antifungal nail creams may cause side effects such as rash.

Surgery

Your health care provider might suggest temporary removal of the nail so that the antifungal drug can be applied directly to the infection under the nail.

The most effective but least used option is surgery to permanently remove the nail and its root.

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Lifestyle and home remedies

Often, you can take care of a fungal nail infection at home:

  • Try nonprescription antifungal nail creams and ointments. Several products are available, such as terbinafine (Lamisil). If you notice white markings on the surfaces of the nails, file them off, soak your nails in water, dry them, and apply the medicated cream or lotion. Even if this clears up your symptoms, it's common for the infection to come back.
  • Trim and thin the nails. This helps reduce pain by reducing pressure on the nails. Also, if you do this before applying an antifungal, the drug can reach deeper layers of the nail.

Before trimming or using a nail file to thin thick nails, soften them with urea-containing creams. See a health care provider for foot care if you have a condition that causes poor blood flow to your feet.

Alternative medicine

Some research suggests that the nutritional supplement biotin might help strengthen weak or brittle fingernails. Talk with your health care provider if you have any questions or concerns about whether this is right for you.

Also, some research shows that tea tree oil has anti-fungal effects. It is often used to treat nail fungus.

Preparing for your appointment

You're likely to start by seeing your primary care provider. In some cases when you call to set up an appointment, you may be referred immediately to either a doctor who specializes in skin conditions (dermatologist) or one who specializes in foot conditions (podiatrist).

Here are some steps you can take to prepare for your appointment:

  • List your symptoms, including any that may seem unrelated to nail fungus.
  • List key personal information, including any major stresses or recent life changes.
  • List all the medications, vitamins and supplements you're taking.
  • List questions to ask your health care provider.

For nail fungus, your questions might include:

  • What is likely causing my symptoms or condition?
  • What are other possible causes for my symptoms or condition?
  • What tests do I need?
  • What is the best course of action?
  • What are the alternatives to the primary approach you're suggesting?
  • I have other health conditions. How can I best manage them together?
  • Is a generic alternative available for the medicine you're prescribing?
  • Do you have any brochures or other printed material that I can take home? Do you recommend any websites on nail fungus?

By Mayo Clinic Staff

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May 15, 2024

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  1. AskMayoExpert. Fungal nail infection (onychomycosis). Mayo Clinic; 2022.
  2. Kelly AP, et al., eds. Nail disorders. In: Taylor and Kelly's Dermatology for Skin of Color. 2nd ed. McGraw Hill; 2016. https://accessmedicine.mhmedical.com. Accessed May 3, 2022.
  3. Onychomycosis. Merck Manual Professional Version. https://www.merckmanuals.com/professional/dermatologic-disorders/nail-disorders/onychomycosis. Accessed May 3, 2022.
  4. Toenail fungus. American Podiatric Medical Association. https://www.apma.org/Patients/FootHealth.cfm?ItemNumber=1523. Accessed May 3, 2022.
  5. Foley K, et al. Topical and device-based treatments for fungal infections of the toenails. Cochrane Database of Systematic Reviews. 2020; doi:10.1002/14651858.CD012093.pub2.
  6. Lipner SR, et al. Onychomycosis: Clinical overview and diagnosis. Journal of the American Academy of Dermatology. 2019; doi:org/10.1016/j.jaad.2018.03.062.
  7. Ameen M, et al. British Association of Dermatologists' guidelines for the management of onychomycosis 2014. British Journal of Dermatology. 2014; doi:10.1111/bjd.13358.
  8. Taylor Frazier W. Onychomycosis: Rapid evidence review. American Family Physician. 2021;104:359.
  9. Gibson LE (expert opinion). Mayo Clinic. May 25, 2022.
  10. Biotin. Natural medicines. https://naturalmedicines.therapeuticreseardch.com. Accessed May 3, 2022.
  11. Tea tree oil. Natural medicines. https://naturalmedicines.therapeuticreseardch.com. Accessed May 3, 2022.

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Nail fungus - Diagnosis and treatment (2024)

FAQs

How do you diagnose nail fungus? ›

A small sample of the infected nail may need to be taken and sent off for testing before treatment starts, to confirm that you do have a fungal infection. If the treatment is working, you should see a new healthy nail start to grow from the base of nail over the course of a few months.

What underlying conditions cause nail fungus? ›

Health.
  • Athlete's foot (or another skin infection caused by fungus)
  • Injured a nail or recently had nail surgery.
  • People in your family frequently get nail infections.
  • Poor circulation.
  • Psoriasis.
  • Received an organ transplant.
  • Weakened immune system due to a disease like human immunodeficiency syndrome (HIV)

What is the fastest way to get rid of nail fungus? ›

Antifungal pills also work more quickly than medicine applied to the nails. Taking antifungal pills for two months can cure an infection under the fingernails. Usually three months of treatment cures a toenail fungal infection.

What is the most effective treatment for nail fungus? ›

Terbinafine should be considered as first line treatment for dermatophyte fungi (the ones that cause athlete's foot). It is taken daily for 6 weeks for fingernail infections and for 12-16 weeks for toenail infections.

What can be mistaken for nail fungus? ›

Nail psoriasis and nail fungus symptoms are similar, and it may be difficult to tell them apart. It's important to know which you have so you can treat it properly. Both conditions can cause nail pitting, thickening, or structural changes but differ in other ways.

Is it better to see a podiatrist or dermatologist for toenail fungus? ›

For prompt, effective treatment of your toe nail condition, you should see a podiatrist as soon as possible, especially if you notice certain changes to your nails. These abnormalities may include toenail deformities, discoloration, or thickening.

What actually kills nail fungus? ›

To treat fungal nail infections from inside the body, you can take tablets that inhibit the growth of fungi or kill them. They are all prescription-only. Terbinafine and itraconazole are typically used for this purpose. Terbinafine is preferred if the nail fungus is caused by a skin fungus (dermatophyte).

Why does Vicks VapoRub work on nail fungus? ›

The rub contains camphor, eucalyptus oil, and menthol, ingredients that have antifungal properties.

What is the sock trick for toenail fungus? ›

Wear socks made of synthetic fiber that “wicks” moisture away from your feet faster than cotton or wool socks do. Disinfect instruments used to cut nails. Disinfect home pedicure tools.

Is hydrogen peroxide good for toenail fungus? ›

Hydrogen peroxide can kill the fungus that grows on toenails. You can use hydrogen peroxide for toenail fungus by wiping it on your infected toes or toenails with a clean cloth or cotton swab. A hydrogen peroxide foot soak can also be used.

What worsens toenail fungus? ›

Older age. Wearing shoes that make your feet sweat heavily. Having had athlete's foot in the past. Walking barefoot in damp public areas, such as swimming pools, gyms and shower rooms.

What is the number one nail fungus remover? ›

If you've decided to try to kill toenail fungus at home, Jodi LoGerfo, a board-certified dermatologist at the Orentreich Medical Group in New York City, suggests Lamisil AT Antifungal Cream as the best over-the-counter treatment.

What tests are done for fungal nails? ›

Arrange for nail clippings and/or scrapings for fungal microscopy and culture to confirm the diagnosis and underlying cause, if the person wishes to consider management with antifungal treatments. Interpret the results as positive if: For dermatophytes, either microscopy or culture is positive.

What are the red flags of a fungal nail infection? ›

Fungal nail infection should be suspected if: The nail looks abnormal and is discoloured. There are white or yellow streaks along one side of the nail.

How do doctors test for fungus? ›

Fungal testing typically includes a microscopic examination of the sample on a slide, sometimes using a preparation or stain to aid in detection of fungal elements. This may be sufficient to determine that the infection is due to a fungus and, with superficial infections, no more tests may be required.

Is toenail fungus a symptom of something else? ›

Other Conditions That Look Like Toenail Fungus

Other conditions that can resemble a toenail fungus are: Psoriasis: Psoriasis is an autoimmune condition affecting the skin and nails. It causes white, yellow, or brown discoloration, pitting, crumbling, blood under the nail, and the nail separating from the toe.8.

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